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Contraindicated (1)pentobarbital will reduce the extent or outcome of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's active metabolites.pentobarbital will raise the amount or effect of clopidogrel by impacting hepatic/intestinal enzyme CYP3

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